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両側下オリーブ核肥大変性を呈した脳幹梗塞 : 特に星状細胞機能と神経可塑性について
https://uekusa.repo.nii.ac.jp/records/338
https://uekusa.repo.nii.ac.jp/records/338eda8d411-d210-4da7-904c-dff209ffb8d2
名前 / ファイル | ライセンス | アクション |
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KJ00008710599.pdf (724.9 kB)
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Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-05-26 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 両側下オリーブ核肥大変性を呈した脳幹梗塞 : 特に星状細胞機能と神経可塑性について | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Bilateral Inferior Olivary Hypertrophic Degeneration associated with Brainstem Infarction : Special Reference to Astrocytic Function and Neuroplasticity | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 下オリーブ核肥大変性 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 経シナプス変性 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 星状細胞 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 神経保護作用 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 脳幹梗塞 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hypertrophic degeneration of the inferior olive | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | transsynaptic degeneration | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | astrocyte | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neuroprotection | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | brainstem infarction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12412714 | |||||
著者 |
内山, 伸治
× 内山, 伸治× 羽賀, 千恵× 秋山, 治彦 |
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抄録(日) | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 要旨:症候性軟口蓋振戦(SPT)を伴い両側下オリーブ核(IO)肥大変性(IOHD)を認めた脳幹梗塞例を報告し, IOHDの病態についてIOの機能的特性と星状細胞の神経保護作用の面から考察した。IOHDは歯状核オリーブ路(DOP)の障害による経シナプス変性であり,神経細胞の変性•脱落と共に慢性的な肥胖星状細胞増多を特徴とする。IOの機能的特性は, DOPを介する小脳からのGABA作動性抑制性入力と中脳•間脳結合域などからの興奮性入力(グルタミン酸作動性と谁測されている)を同時に受け, 小脳プルキンユ細胞に登上線維を出力し, 発振器として運動学習や運動誤差修正に働くことである。一方,星状細胞の様々な機能の中で,グルタミン酸依存性のシナプス伝達調節作用が, 神経保護の面から注目されている。DOPの障害により抑制性入力が途絶し, 過剰な興奮性入力(恐らくグルタミン酸作動性)にさらされたIOのシナプスでは, その可塑性に向けてIO神経細胞と星状細胞との間に, 懸命なかつ絶望的とも言える相互作業が続く。その中で,次第に神経細胞変性と星状細胞の肥大が進打し, やがて徐々に神経細胞は脱落に向かう。しかし, IOはなお長期間活動的であり, 抑制を失った発振器としてのIOは, 臨床的にはSPTを発現し続ける。 IOHDは単なる変性ではなく, 抑制性入力が途絶したIO神経細胞と星状細胞の両者により織りなされる, 神経可塑性に向けてのmodulation過程と考えられる。IOHDの病態には, IO神経細胞の機能的特性と共に星状細胞の神経保護作用が重要である。 |
|||||
言語 | ja | |||||
抄録(英) | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Abstract: Inferior olivary hypertrophic degeneration (IOHD), the distinguishing features of which are neuronal degeneration and chronic gemistocytosis, is thought as being a transsynaptic degeneration resulting from the interruption of the dentato-olivary pathway (DOP). Bilateral IOHD associated with brainstem infarction with symptomatic palatal tremor (SPT) was reported here. In addition, the pathology of IOHD was discussed on the basis of the structural and functional properties of the olive and astrocytes. In the neural network called the three-element loop, olivary dendritic spines receive both inhibitory GABAergic inputs via the DOP and excitatory inputs (which are presumed to be glutamatergic) from the mesodiencephalic junction. By sending climbing fibers to the cerebellar Purkinje cells, the olive is considered to work as an oscillator for motor learning and motor-error correction. Among the various functions of astrocytes, the glutamate dependent synaptic regulation by these cells is an emerging concept In the presence of interruption of inhibitory inputs, both olivary neurons and astrocytes make serious, but rather desperate, efforts toward neuroprotection from excessive excitatory (probably glutamatergic) inputs, followed by gradual progression of neural degeneration and astrocytic hypertrophy. In IOHD, the olive may remain hyperactive for a long time after the onset of the causative disease; thus, the SPT may continue throughout tifo as an expression of the dysfunction of the olivary oscillator. IOHD is not only a degenerative, but also a modulating process for neuroplasticity that occurs in the neuron astrocyte interaction after the loss of inhibitory inputs to the olive. In addition to the unique properties of olivary neurons, the potential role of astrocytes in neuroprotection is crucial for the development of IOHD. |
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言語 | en | |||||
書誌情報 |
ja : 植草学園大学研究紀要 en : Bulletin of Education and Health Sciences, Uekusa-Gakuen University 巻 5, p. 127-136, ページ数 152, 発行日 2013-03-01 |
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表示順 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 17 | |||||
アクセション番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | KJ00008710599 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 18835988 |